بررسی اثرتجویز شیاف ایندومتاسین در کاهش مصرف مخدرها بعد از جاندازی شکستگی کالیس

Introduction & Objective: Postoperative acute pain is a complex reaction to tissue injury , visceral distention or a disease that causes harmful physiologic effects on several organs. It seems that with more epidemiologic and pathologic knowledge of postoperative pain, patients can be relieved more and hospital expenses reduced. One of the methods to reduce postoperative analgesics requirement is the preemptive analgesia. Many drugs like NSAIDs and narcotics have been used. The aim of this article was to study the effect of a single dose Indomethacin suppository given before operating colles fracture to reduce postoperative analgesics requirement. Materials & Methods: In this clinical study patients were divided into two groups randomly. The case group (55 people) received 100 mg indomethacin thirty minutes before anesthesia , while the control group (45 people) received nothing . All had the same kind of anesthesia , which lasted less than an hour for all . After operation they received NSAIDs or narcotics according to the Flacc pain scale. Results: The average NSAID received after the operation in the case group was 16.8±23.1 mg, and 30.5±33.6 mg in the control group. Studying these values with t- test illustrates that using preoperative indomethacin causes less postoperative NSAID requirement (P<0.05). The average opioid equivalent dose given in the case group was 1.3 ±2.9 mg and 6.2±8.3 mg in the control group , demonstrating less opioid requirement in the case group(P<0.05). Conclusion: Prescribing a single dose indomethacin suppository before colles fracture operation has preemptive analgesic effect and reduces postoperative analgesic requirement.